How to Remove Ceramic Tile Backsplashes | DoItYourself.com Step 1 - Prepare the Tile. Begin the process by cleaning the entire backsplash with a tile cleaning solution. Apply the cleanser with a sponge, allow it to sit for four to five minutes, and then wipe it clean with a towel. It is important to get the grout and the tiles completely clean, so use plenty of solution and elbow grease if needed.